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Repeating Patterns of Sleep Restriction and Recovery

Repeating Patterns of Sleep Restriction and Recovery - do we Get Used to it?

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT01523691
Enrollment
17
Registered
2012-02-01
Start date
2011-08-31
Completion date
2016-06-30
Last updated
2017-03-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy

Keywords

Healthy individuals

Brief summary

Goal of this study is to test the hypothesis that repeated exposure to cycles of insufficient sleep increases susceptibility to a variety of disease states by progressively compromising the integrity of stress response systems.

Interventions

BEHAVIORALRepeated sleep restriction and recovery

Repeated cycles of sleep restriction and sleep recovery

BEHAVIORALControl sleep

Regular amounts of sleep across study protocol

Sponsors

National Heart, Lung, and Blood Institute (NHLBI)
CollaboratorNIH
Beth Israel Deaconess Medical Center
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender
ALL
Age
18 Years to 35 Years
Healthy volunteers
Yes

Inclusion criteria

* Body mass index (BMI) between 18.5 and 30 kg/m2 * For female participants: regular menstrual cycles * Daily sleep duration in the normal range * Blood chemistry in the normal range

Exclusion criteria

* Active infection/disease * History of psychiatric, neurological, pain-related, immune, or cardiovascular disease; significant allergy * Pregnant/nursing * Respiratory disturbance index of \>5 events/hour on polysomnographic sleep study, leg movements with arousal \>10/hour; sleep efficiency \<80% * Regular medication use other than oral contraceptives * Donation of blood or platelets 3 month prior to or in-between study arms

Design outcomes

Primary

MeasureTime frameDescription
stress-related markersParticipants will be followed for the duration of hospital stay, an axpected average of 2 x 25 days.cortisol, ACTH, norepinephrine, IL-6, COX in blood/urine, among others

Secondary

MeasureTime frameDescription
subjective stress-related markersParticipants will be followed for the duration of hospital stay, an axpected average of 2 x 25 days.Computerized rating scales for the assessment of physical and emotional well-being

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026