Preventing Myocardial Ischemia by Preconditioning in Elective Operation for Abdominal Aortic Aneurysm

The Effect of Preconditioning to Prevent Perioperative Myocardial Ischemia in Elective Operation of Abdominal Aortic Aneurysm

Status

UNKNOWN

Phases

Phase 1

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01523262

Enrollment

200

Registered

2012-02-01

Start date

2011-01-31

Completion date

2016-01-31

Last updated

2015-01-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Aortic Aneurysm

Keywords

preconditioning, aortic aneurysm

Brief summary

Primary To investigate whether peripheral predonditioning induced by brief, intermittent constriction of blood supply to an arm can reduce the incidence of perioperative myocardial ischemia in patients operated electively for infrarenal aortic aneurysm. Secondary To investigate the impact of peripheral preconditioning on perioperative inflammatory response. To investigate whether peripheral preconditoning can protect against perioperative myocardial infarction and reduced cardiac pump function.

Interventions

PROCEDUREpreconditioning

peripheral preconditioning induced by brief, intermittent constriction of blood supply to an arm

PROCEDURENormal surgery, with sham intervention without inflating arm cuff

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* All patients older than 18 years, hospitalized for elective surgery of abdominal aortic aneurysm

Exclusion criteria

* Lack of informed consent. * Hemiparetic patient. * Pregnancy or nursing patient.

Design outcomes

Primary

Measure	Time frame
measurements of CKMB and Troponin T	30 days

Countries

Denmark

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026