Healthy
Conditions
Brief summary
Data and knowledge gathered on bioavailability of coffee phenolics is becoming more and more important, hence underlying the importance of better understanding the fate of these potential health promoting antioxidants. However, some analytical barriers as well as some key aspects of metabolism still remain to be fully elucidated to get the full picture of coffee metabolism and bioavailability. One aspect addressed in the present study is the impact of food matrix in modulating absorption, plasma appearance and urinary excretion of coffee bioactives.
Interventions
OTHERSoluble Coffee
Amounts of chlorogenic acids will be normalized to body weight (3.1 mg CA / kg BW). Coffee will be reconstituted in 200 mL hot water and consumed 3 times in a row (min 1-week interval), alone or with a breakfast: * 200 mL coffee or * 200 mL coffee + 2 bread rolls + honey * 200 mL coffee + 1 bread roll + peanut butter
Sponsors
Société des Produits Nestlé (SPN)
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
20 Years to 44 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy men and women * Aged 20-44 years * Caucasian origin * Body mass index (BMI) 19-25 kg/m2 * Used to drinking coffee (similar to study coffee) on a daily basis * Being able to tolerate a 48-hour coffee abstinence * Normal oral glucose tolerance test * Having signed the informed consent form
Exclusion criteria
* Taking medication or dietary supplements * Smoking * Performing a competitive sport * Having metabolic disorders * Long gut transit time (\>24 h) * Blood donor * Irregularity in menstrual cycle (for women) * Pregnancy (for women) * Subject who cannot be expected to comply with the study procedures. * Currently participating or having participated in another clinical trial during the last 4 weeks prior to the beginning of this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sum of plasma areas under the curve of coffee phenolics | Measurements over 24h after coffee ingestion |
Secondary
| Measure | Time frame |
|---|---|
| Plasma AUC, Cmax and Tmax of individually measured coffee chlorogenic and phenolic acids | Measurements done over 24h after coffee ingestion |
| Urinary excretion of coffee chlorogenic and phenolic acids expressed as % ingested dose | Measurements done over 24h after coffee ingestion |
Countries
Germany
Outcome results
None listed