Focus of the Study is Insulin Sensitivity
Conditions
Keywords
insulin sensitivity, resistant starch
Brief summary
This study will examine the effects of a dietary fiber on insulin sensitivity in overweight and obese women. The fiber will be added to snack foods and women will consume the foods for four weeks. In one four-week period, 15 g of fiber will be added, and 30 g will added in another period. In a third period, no fiber will be added to the snack foods. Insulin senstivity will be measured at the end of each treatment period.
Interventions
DIETARY_SUPPLEMENTDietary Fiber
Dietary fiber will be added to snack foods
Sponsors
Ingredion Incorporated
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
19 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* Impaired fasting glucose * Overweight and obese
Exclusion criteria
* Diabetes, Presence of chronic diseases
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Insulin sensitivity | 5-hr test, performed 3 times within a 20-week period | A frequently sampled intravenous blood glucose tolerance test will be performed. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Mitocondrial function | 3 times, with a 20-week period | A muscle biospy will be taken to assess mitochondrial function |
| Meal tolerance test | 3 times, within a 20-week period | A high-fat meal will be given and blood will be drawn over a three-hr period |
Countries
United States
Contacts
Primary ContactBrandon Kane
Outcome results
None listed