Oropharyngeal Microbiology
Conditions
Keywords
Probiotics, Anaesthesia, Intubation, Pathogenic bacteria
Brief summary
Longer surgical procedures require intubation and there is a potential risk of contaminating the lower airways with pathogenic bacteria from the mouth and oropharynx. Healthy people seldom have pathogenic bacteria originating from the gastro-intestinal canal but those do occur among patients, both in those not so sick and patients with more severe problems. For ICU patients we have seen a reduction of emerging enteric bacteria in patients given oral care with probiotics and this is a pilot study to explore the possibility of the same kind of positive effects in patients due for longer (more than 4 hours of anesthesia) procedures. Randomisation * No prophylaxis * Preparation with a probiotic suspension before intubation. Cultures * oropharynx * before treatment * after intubation * before extubation * day 1 postoperatively * tracheal secretions * after intubation * before extubation
Interventions
DIETARY_SUPPLEMENTProbiotics
Patients will gurgle and swallow a mixture of probiotic bacteria
Sponsors
Lund University
Region Skane
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adult patients * Planned interventions * Anaesthesia \> 4 hours and requiring intubation
Exclusion criteria
* Ulcers in the mouth, oropharynx, oesophagus and stomach * Current infections in the airways * Known immuno deficiences * Emergency cases
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Differences in pathogenic bacteria in the oropharynx and lower airways | During hospitalization, up to 4 weeks | Emerging and resident bacteria will be compared for the cultures taken in the oropharynx and from tracheal secretions in conection with anaestesia and a surgical intervention |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| White blood cells | During hospitalization, up to 4 weeks | WBC taken pre-op and days 1,2,3 post-op |
| CRP | During hospitalization, up to 4 weeks | CRP taken pre-op and days 1,2,3 post-op |
| Pneumonia | Up till 7 days postoperatively | X-ray verified infiltrations in combination with expectorates |
| Length of hospital stay | time to discharged from hospital or patients death | Comparison of length of stay between the intervention group and the control group |
Countries
Sweden
Outcome results
None listed