Critical Illness, Muscle Disuse, Neuromuscular Electrical Stimulation (NMES)
Conditions
Brief summary
Subjects who are hospitalized in the ICU will be included after 24 hours of intubation during their ICU stay. Twice-daily Neuromuscular Electrical Stimulation (NMES) will be performed on one leg for 2x40 min per day to assess muscle fiber size. The investigators hypothesize an attenuated loss in muscle fiber size.
Interventions
PROCEDURENeuromuscular Electrical Stimulation of m. quadriceps femoris
Neuromuscular Electrical Stimulation of m. quadriceps femoris by using a commercially available muscle stimulator
PROCEDURESham-treatment: no NMES
Sham comparator
Sponsors
Hasselt University
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Male * Age between 18 and 80 years * Expected sedated time of \>24h
Exclusion criteria
* Spinal Cord Injury * Arterial operaties on the legs * Local wounds that prohibit NMES * Chronic use of corticosteroids * Intake of certain antithrombotic drugs * Presence of implantable cardioverter defibrillator and/or pacemaker
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in muscle fiber cross sectional area (CSA) | 3 hours before and 12 hours after 10 days of twice-daily NMES | Muscle fiber cross sectional area (in um2) for type I and II fibers will be analyzed by using immunohistochemistry; the change of muscle fiber CSA over time will be measured |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in upper leg circumference | 3 hours before and 12 hours after 10 days of twice-daily NMES | Upper leg circumgerence will be measured; the change of upper leg circumference over time will be measured |
Countries
Belgium
Outcome results
None listed