Airway Obstruction, Smoking
Conditions
Keywords
chronic obstructive pulmonary disease,, bronchial reversibility,, bronchodilator,, respiratory impedance,, forced oscillation technique,, plethysmography,, spirometry, Diagnostic Techniques, Respiratory System
Brief summary
The aim of this study is to assess the bronchodilator response of salbutamol on respiratory mechanics of healthy individuals, smokers and COPD with varying degrees of airway obstruction.
Detailed description
Clinical evaluation will be conducted and anthropometric measurements, then the pulmonary function tests: forced oscillation technique (FOT), whole body plethysmography, spirometry and-administration of salbutamol aerosol for assessment of bronchodilator response. After 20 minutes, the individual will be evaluated again following the same sequence.
Interventions
bronchodilator test, beta2-agonist, short-acting, six hours duration, 400 micrograms.
Sponsors
Conselho Nacional de Desenvolvimento Científico e Tecnológico
Rio de Janeiro State Research Supporting Foundation (FAPERJ)
Rio de Janeiro State University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
40 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* healthy individuals, smokers and patients with chronic obstructive pulmonary disease.
Exclusion criteria
* healthy subjects: no history of smoking respiratory infection and disease respiratory * smokers and chronic obstructive pulmonary disease patients: asthma and other respiratory diseases.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Respiratory function test | two o'clock | Evaluation of pulmonary mechanics before and after salbutamol (short-acting bronchodilator) in healthy individuals, smokers and chronic obstructive pulmonary disease in stages: mild, moderate, severe and very severe according to GOLD criteria. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Salbutamol | twenty minutes | In the bronchodilator test will be used 400 micrograms of beta2-agonist short-acting. They will be asked to exhale slowly until they can no longer expel more air from the lungs. To place the inhaler with a spacer between the lips, pressing them well, but no bite. Shortly thereafter start to breathe through the mouth and will be released a jet of 100 micrograms of the bronchodilator. Then they will hold their breath for 10 seconds. 3 puffs are made with 1 minute interval between each application. |
Countries
Brazil
Contacts
Primary ContactAgnaldo J Lopes, PhD
Backup ContactPedro L de Melo, PhD
Outcome results
None listed