Coronary Artery Disease
Conditions
Keywords
Diagnostic imaging, Single Photon Emission Computed Tomography, Positron emission tomography, Computed tomography, Attenuation, Resolution, Scatter, Radiopharmaceutical
Brief summary
Single Photon Emission Computed Tomography (SPECT) is a 3D nuclear medicine imaging technique that is used extensively to study the heart and diagnose heart disease. There are three major limitations in SPECT imaging: attenuation or loss of signal, scattering of the signal in the patient tissues and resolution, where the signal gets blurrier the further the nuclear activity is away from the camera. New software, Evolution for CardiacTM, by GE Healthcare and new cameras with computed tomography (CT) decrease the time needed for images to be obtained while maintaining image quality. Evaluation is needed before they become standard of care.
Interventions
RADIATIONSPECT/CT processed with Evolution for CardiacTM software
SPECT/CT to be compared with PET/CT
Sponsors
Ottawa Heart Institute Research Corporation
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Intermediate to high risk patients with coronary artery disease who are scheduled for routine SPECT or PET perfusion imaging
Exclusion criteria
* Pregnancy and breast feeding * Severe narrowing (stenosis) of the aortic valve * Severe heart failure
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| • Determine the accuracy of myocardial perfusion assessment using SPECT with AC/SC/RR compared to Rb-82 PET. | 2 years | We are proposing a study to evaluate the accuracy of SPECT with the new technologies for attenuation correction (AC), scatter compensation (SC) and resolution recovery (RR) for the assessment of myocardial perfusion in patients with heart disease using Rb-82 perfusion PET as the gold standard for comparison. |
Secondary
| Measure | Time frame |
|---|---|
| Determine the incremental benefit of AC/SC/RR compared to AC alone | 2 years |
| Evaluate the effect on accuracy of using software with RR to reduce the acquisition time to half of the standard time. | 2 years |
| Determine if using a registered diagnostic CT (PET) increases the accuracy of CT-based AC over the lower-quality Hawkeye CT (SPECT). | 2 years |
| Determine if using a single CT scan acquired at stress for attenuation correction of both stress and rest SPECT decreases the accuracy over using CT scans acquired separately at rest and stress. | 2 years |
Countries
Canada
Outcome results
None listed