Hemiparesis, Stroke
Conditions
Keywords
stroke
Brief summary
Noninvasive brain stimulations (NIBS) will be used in chronic stroke patients to improve motor learning. Functional magnetic resonance imaging will be used to evaluate the mechanisms underlying motor learning in healthy volunteers and in chronic stroke patients.
Detailed description
transcranial direct current stimulation will be used for NIBS
Interventions
tdcs (ELDITH, Neuroconn, Ilmenau, Germany)
DEVICEtranscranial magnetic stimulation TMS
TMS (The Magstim Company Ltd, UK) Magstim 200² with a figure-of-eight coil was used to determine the hot spot eliciting consistent movements in the contralateral hand
Sponsors
University Hospital of Mont-Godinne
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 95 Years
Healthy volunteers
Yes
Inclusion criteria
* stroke with at least slight deficit
Exclusion criteria
* epilepsy * contraindication to tDCS and/or to fMRI * presence of metal in the head * inability to understand / complete behavioral tasks * chronic intake of alcohol or recreational drugs * major health condition * presence of pacemaker (for the fMRI part only) * pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Motor learning improvement with tDCS | Improvement on motor learning were recorded from baseline to 4 weeks after the intervention | performance on a motor skill learning task and on different commonly used task (Purdue Pegboard, hand dynamometer, pinch dynamometer, 9-HPT ,...) were measured to explore the impact of tDCS on these parameters |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Neuroimaging | before motor learning, during motor learning and after (immediately, 30,60min) motor learning (with or without tDCS) | Does cerebral mechanisms underlying motor learning differ from healthy subject to stroke patients? |
| Neurophysiological outcome measure | start of session 5min before motor learning, just at the end of the motor learning, after 30 min of motor learning, after 60 min of motor learning, Recall test at 1,2,3,4 weeks after the day of intervention (with or without tDCS) | measure of brain excitability and connectivity with TMS (single and paired pulse) |
Countries
Belgium
Outcome results
None listed