Hepatocellular Carcinoma
Conditions
Keywords
hepatocellular carcinoma
Brief summary
Radiation-induced liver disease (RILD) is a syndrome characterized by the development of anicteric ascites approximately 2 weeks to 4 months after hepatic irradiation. Previous studies have shown that both the volume of liver irradiated and the dose of radiation delivered are prominent factors for development of RILD. While use of a population-based normal tissue complication probability model allows investigators to limit the risk of RILD to a clinically acceptable level, a test that permits investigators to determine an individual's risk of RILD during the course of treatment may allow for individualized treatment modifications, either to prevent toxicity or increase efficacy.
Detailed description
Early, but subclinical physiologic changes in the liver may be associated with the future development of RILD. There are currently limited data on how a local change in hepatic function associates with regional radiation dose, and how the change of hepatic function during and after radiation therapy (RT) associates with RILD. In the present study, a radiological methodology that is minimally invasive will be used to measure volumetric hepatic functions in patients with intrahepatic malignancies before, during, and after a course of fractioned radiation therapy.
Interventions
RADIATIONLiver Irradiation
Patients already scheduled to undergo radiation treatment
Sponsors
University of Michigan Rogel Cancer Center
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* cancer patients undergoing radiation of the Liver * women and men who agree to avoid pregnancy * life expectancy of at least 6 months
Exclusion criteria
* pregnant women * breatsfeeding women * prisoners
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes in hepatobiliary single photon emission tomography (SPECT) after radiation therapy | 6 months | Changes in SPECT, which reflect hepatocyte function, will be correlated with specific regions of radiation dose to determine a relationship between dose and radiation-induced damage. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| measuring values between regional radiation dose and local hepatic function as measured by hepatobiliary SPECT, in normal liver parenchyma | 6 months | dynamic hepatobiliary single photon emission tomography (SPECT) values will assess changes in hepatocyte function in patients with intrahepatic malignancies receiving radiation therapy. Perhaps a relationship between SPECT and dosage can be determined. |
Countries
United States
Outcome results
None listed