Coronary Artery Disease
Conditions
Keywords
Coronary Artery Disease
Brief summary
This is a pilot study to see whether cardiac imaging can be performed using half the standard dose of radioisotope.
Detailed description
The aim of this study is to compare the image quality of the half radioisotope dose scans obtained using a CZT (cadmium zinc telluride) camera with scans acquired using a standard of care imaging protocol/radioisotope dose performed on a traditional (conventional) camera. The proposed strategy of a half dose/extended time protocol with the CZT camera should yield a similar count activity and consequently image quality equivalent to that detected by a conventional SPECT system.
Interventions
OTHERHalf-dose isotope for NuclearStressTest
Half-dose of tracer or radioisotope will be used for Nuclear stress test of the heart. This is imaging test of the heart to see the function of arteries of the heart.
Sponsors
The Methodist Hospital Research Institute
S.M.Chang, MD
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* ≥ 18 years of age and referred for a clinically-indicated stress SPECT MPI study * suspected or known coronary artery disease * written informed consent
Exclusion criteria
* Evidence of a normal baseline scan after at least 50% of the protocol acquired baseline scans have been interpreted as being normal * Participation in another investigational study within the preceding month * Pregnant and/or breast-feeding female * ECG evidence of left bundle branch block or paced rhythm * Evidence of non-ischemic cardiomyopathy * Presence of hypertrophic cardiomyopathy and/or severe valvular heart disease * Severe claustrophobia or inability to lie flat for 20 minutes (the anticipated amount of time to complete the procedure) * Known allergy to technetium-99m * Potential contraindications to regadenoson use, due to severe lung disease; severe bradycardia (heart rate \< 40 beats/min); second- or third degree atrioventricular heart block; sick sinus syndrome; long QT syndrome; severe hypotension; or decompensated heart failure.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Image quality of the half-dose CZT versus full dose scans | 1 Week |
Secondary
| Measure | Time frame |
|---|---|
| Total radiation dose/exposure of the half-dose CZT vs. full dose scans | 1 Week |
| Total myocardial count activity and count rates obtained during each scan | 1 Week |
| Agreement between the half-dose CZT vs. full dose scans on the presence and extent of fixed or reversible defects on a per-patient and vessel basis | 1 Week |
| Agreement between the half-dose vs. full dose scans on gated data such as EF, left ventricular (LV) end-diastolic volume, LV end-systolic volume | 1 Week |
Countries
United States
Outcome results
None listed