Pediatric Patients Undergoing a Computed Tomography Examination
Conditions
Brief summary
Patients undergoing a computed tomography are exposed to a relatively high dose of X-rays. Pediatric patients are known to be very radiosensitive with respect to radiation induced cancer. Using the technique of scoring γ-H2AX foci in peripheral blood lymphocytes the most important lesions to the genetic material DNA, double strand breaks induced by CT X-rays can be detected. The technique will be applied in a multicenter setting for evaluation of X-effects induced by a computed tomography examination in a population of pediatric patients. To this end a blood sample will be taken from the patients before and after the examination.
Interventions
PROCEDUREBlood test
Analysing X-ray induced genetic effects in pediatric patients directly after a computer tomography scan.
Sponsors
Federal Agency for Nuclear Control, Belgium
University Ghent
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
No minimum to 12 Years
Healthy volunteers
No
Inclusion criteria
* pediatric patients wearing a catheter
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| X-ray induced genetic effects in pediatric patients directly after a computed tomography scan. | Within 30 min after the computed tomography examination. | Assessment of γ -H2AX foci in peripheral blood lymphocytes. |
Countries
Belgium
Outcome results
None listed