Brown Fat Activity and White Fat Accumulation

Study on the Association Between Brown Adipose Tissue Activation and White Adipose Tissue Accumulation in Successfully Treated Pediatric Malignancy

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01517581

Enrollment

Registered

2012-01-25

Start date

2008-10-31

Completion date

2011-09-30

Last updated

2012-01-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hodgkins Lymphoma, Non-hodgkins Lymphoma

Keywords

Brown adipose tissue

Brief summary

White and brown adipocytes differ in their expression of hormones, cytokines, and inflammatory factors, and they modulate different biological functions. While white adipose tissue (WAT) serves as the primary site of energy storage, brown adipose tissue (BAT) instead metabolizes fat to produce heat and regulate body temperature. BAT is likely present in all humans, but the low prevalence of BAT depiction in adults and elderly subjects has hindered longitudinal assessments of the relation between BAT activity and WAT. Under typical imaging conditions, BAT is detected more frequently in children and teenagers than in adults with malignancy. Since most children with cancer have significantly shorter treatment courses and greater survival rates compared to adult patients, the investigators have the ability to examine the relation of repeated measures of body composition and BAT by selecting pediatric patients. In this study, the investigators will longitudinally examine whether BAT activity is related to changes in weight and the amounts of SAT, VAT, and abdominal muscle in children successfully treated for pediatric cancer.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

6 Years to 18 Years

Healthy volunteers

Inclusion criteria

* Patients had PET/CT scans with evidence of malignant disease * Patients had no metabolically active BAT at diagnosis on their PET/CT scan * Patients were disease free within 1 year of diagnosis

Exclusion criteria

* Patients had PET/CT scans with no evidence of malignant disease * Patients with metabolically active BAT at diagnosis on their PET/CT scan * Patients were not disease free within 1 year of diagnosis

Design outcomes

Primary

Measure	Time frame
Change from Baseline in Subcutaneous Adipose Tissue Volume at Follow-up	Baseline and up to 1 year
Change from Baseline in Visceral Adipose Tissue Volume at Follow-up	Baseline and up to 1 year
Change from Baseline in Presence of Brown Adipose Tissue	Baseline and up to 1 year
Change from Baseline in Abdominal Musculature Volume	Baseline and up to 1 year

Secondary

Measure	Time frame	Description
Change from Baseline in Anthropometric Measures at Follow-up	Baseline and up to 1 year	Age, height, weight and BMI

Countries

United States

Outcome results