Major Depressive Disorder
Conditions
Brief summary
The study will investigate the effectiveness of Cognitive Therapy and Acceptance and Commitment Therapy in a randomized controlled trial among patients with Major Depressive Disorder in routine clinical practice. Furthermore, the study will investigate whether each specific treatment approach is mediated by its proposed theoretical mechanism.
Detailed description
The current study aims at investigating the effectiveness of Cognitive Therapy and Acceptance and Commitment Therapy in a randomized controlled trial among patients with MDD in routine clinical practice. Further, the study will investigate whether each specific treatment approach is mediated by its proposed theoretical mechanism. Patients have to meet diagnostic criteria for nonpsychotic MDD as determined by the Structured Interview for DSM-IV. Each client will receive either Cognitive Therapy or Acceptance and Commitment Therapy that will last between 16 to 20 sessions. Based on previous results, it is expected that both treatment forms will prove beneficial for the patients.
Interventions
BEHAVIORALCognitive Therapy
This interventions will target: (a) behavioral dysfunction, (b) situation-specific negative thinking and cognitive distortions, and (c) underlying dysfunctional beliefs or cognitions assumed to be related to the patient's current depression and risk of future depression. A maximum of 20 45-55 minute sessions will be provided, with sessions generally held weekly for the first 8 sessions and once every two weeks for the next 8 sessions.
BEHAVIORALAcceptance and Commitment Therapy
This interventions will use (a) acceptance, (b) commitment, (c) mindfulness, and (d) behavior change processes to produce reduction of depressive symptoms. A maximum of 20 45-55 minute sessions will be provided, with sessions generally held weekly for the first 8 sessions and once every two weeks for the next 8 sessions.
Sponsors
VU University of Amsterdam
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
1. Meeting DSM-IV criteria for MDD 2. Between the ages of 18 and 65-years-old 3. Having sufficient fluency in Dutch to complete treatment and research protocol
Exclusion criteria
1. DSM-IV criteria for bipolar disorder (past or present) 2. Psychotic disorders 3. Substance dependence disorders (current or within the past 6 months), or 4. Organic brain syndrome. 5. Borderline or antisocial personality disorder
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| QUICK INVENTORY OF DEPRESSIVE SYMPTOMATOLOGY (QIDS-SR) | pre-treatment, post-treatment, 6 and 12 months follow-up | Change from pre-treatment to post-treatment, 6 months follow-up and 12 months follow-up |
| Hamilton Rating Scale for Depression | pre-treatment, post-treatment | Change from pre-treatment to post-treatment. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Dysfunctional Attitude Scale-revised | Pre-treatment, in-treatment, and 6 and 12 months follow-up | Change between sessions to follow-up. |
| Working Alliance Inventory | 3. session | — |
| Eurohis Quality of Life Scale | Pre-, post-treatment, 6 and 12 months follow-up | Change pre-treatment to post-treatment and to follow-up. |
| Decentering subscale of the Experiences Questionnaire | Pre-treatment, in-treatment, and 6 and 12 months follow-up. | Change between sessions and to follow-up. |
| Implicit Attitude Test | Pre- and posttreatment | Change pre-treatment to post-treatment |
| Structured Clinical Interview for DSM-IV (Major Depression Module) | Pre-treatment and post-treatment. | Change in diagnosis of Major Depression Disorder from pre-treatment to post-treatment. |
| Relationship Scales | Pre-, post-treatment, 12 months follow-up | Change pre-treatment to post-treatment and to follow-up. |
| Acceptance and Action Questionnaire | Pre-treatment, in-treatment, and 6 and 12 months follow-up. | Change between sessions and to follow-up. |
Countries
Netherlands
Outcome results
None listed