Evaluating Cardiovascular Phenotypes Using Induced Pluripotent Stem Cells

Status

Enrolling by invitation

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01517425

Acronym

iPSC

Enrollment

200

Registered

2012-01-25

Start date

2012-11-30

Completion date

2030-07-31

Last updated

2025-01-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary Artery Disease

Brief summary

This research is being done to understand how changes in DNA may put people at risk for developing coronary artery disease. Stem cells will be made using cells from blood and/or skin biopsy samples. We are trying to understand which specific changes in DNA negatively impact a person's health.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

Cases: 1. Previously enrolled in the CAD module of the Genebank at Scripps Clinic Registry 2. Eligible to have their blood drawn 3. Be reliable, cooperative and willing to comply with all protocol-specified procedures 4. Able to understand and grant informed consent Controls: 1. Previously enrolled in the Healthy Elderly Active Longevity (HEAL) Cohort 2. Eligible to have their blood drawn 3. Be reliable, cooperative and willing to comply with all protocol-specified procedures 4. Able to understand and grant informed consent

Exclusion criteria

1. Unwilling or unable to grant informed consent. 2. Have a significant medical condition that in the Investigator's opinion may interfere with subject's study participation.

Design outcomes

Primary

Measure	Time frame	Description
iPSC development	five years	Develop methods of iPSC generation from patients with genomic risk.

Countries

United States

Outcome results