Screening of Healthy Adults for Genetic Variations That Control Fatty Acid Processing

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01516125

Enrollment

458

Registered

2012-01-24

Start date

2011-09-30

Completion date

2019-04-17

Last updated

2023-11-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy

Keywords

healthy adult, genetic variation, botanical oils, polyunsaturated fatty acid, fish oil, fat metabolism, Genetic variation of fat metabolism in healthy adults

Brief summary

The purpose of this research study is to screen healthy African American and Caucasian persons for specific differences in genes that control how fats are processed in the body.

Detailed description

Healthy African American and Caucasian persons will be screened for specific differences in genes that control how fats are processed in the body. Persons with the needed genotypes will be added to a database of healthy persons who may be asked to join a larger study comparing differences in diet on lipid metabolism and inflammatory biomarkers as well as future studies. A key hypothesis for the larger study is that variations in genes involved in lipid metabolism play a role in determining levels of long chain polyunsaturated fatty acids (LC-PUFAs).

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

21 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

* Be Caucasian or African American between 21-65 years of age * Be healthy and free of any major illness * Be a nonsmoker * Have an intact gallbladder * Have TG \< 150 and blood pressure less than 130/90 * Must be willing to be re-contacted for future studies

Exclusion criteria

* Not have: myocardial infarction, vascular surgery or stroke within the past year * Not be taking niacin, more than 100 mg aspirin/day or montelukast allergy medications * BMI equal to or greater than 30 or less than 19 * Fasting glucose greater than 125 mg/dl * Pregnancy

Design outcomes

Primary

Measure	Time frame
Determine the genotype at the rs174537 single-nucleotide polymorphism (SNP) in the fatty acid desaturate (FADS) gene cluster	up to 52 months

Countries

United States

Outcome results