How Fat Influences the Brain

Fat Intake Modulates Cerebral Blood Flow in Homeostatic and Gustatory Brain Areas in Humans

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01516021

Enrollment

Registered

2012-01-24

Start date

2011-01-31

Completion date

2011-03-31

Last updated

2012-01-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Fat Processing in the Brain

Keywords

Fat ingestion, hypothalamus, insula, fMRI, CBF

Brief summary

The aim of the current study was to investigate the effect of a high versus a low fat meal (operationalized by high and low fat yoghurt) on homeostatic and gustatory brain regions.

Interventions

DIETARY_SUPPLEMENTintake of high or low fat yoghurt

intake of 500 ml of a high fat yoghurt on one day and intake of 500 ml of a low fat yoghurt on the other day

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

MALE

Age

25 Years to 32 Years

Healthy volunteers

Yes

Inclusion criteria

* male * healthy

Exclusion criteria

* lactose intolerance * fMRI contraindications (metal implants,...)

Design outcomes

Primary

Measure	Time frame	Description
Changes in Cerebral Blood Flow due to the high or low fat yoghurt intake after 30 minutes and 120 minutes compared to a baseline measurement 30 minutes before yoghurt intake.	30 minutes before as well as 30 minutes and 120 minutes after fat intake	We were interested in differential brain activations due to the high or low fat meal. To assess this, the mentioned time points are suitable. The Cerebral Blood Flow is measured using Arterial Spin Labeling sequences in a functional magnetic resonance tomography.

Countries

Germany

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 26, 2026