Systemic Lupus Erythematosus
Conditions
Brief summary
The investigators hypothesize that a three-month aerobic exercise training program will positively affect the lipid profile, insulin sensitivity , cytokine profile, the cardiovascular parameters and muscle strength in SLE patients.
Interventions
BEHAVIORALExercise training
Aerobic exercise training, two times a week
Sponsors
University of Sao Paulo
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
7 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
* Age between 7 and 40 years * SLEDAI ≤ 4
Exclusion criteria
* Cardiovascular dysfunction * Rhythm and conduction disorders * Musculoskeletal disturbances * Kidney and pulmonary involvements * Peripheral neuropathy * Use of tobacco * Treatment with lipid-lowering or hypoglycemic drugs * Fibromyalgia * Use of chronotropic or antihypertensive drugs * Physically active subjects
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Lipid profile - Plasma levels of total cholesterol (mg/dl), VLDL-chol (mg/dl) HDL-chol (mg/dl), LDL-chol (mg/dl), triglycerides (mg/dl), Apolipoprotein AI and AII (mg/dl) and Apolipoprotein B (mg/dl) | 3 months |
| Insulin sensitivity as measured by the Hyperinsulinemic-Euglycemic Clamp | 3 months |
| Cytokine response - Plasma levels of TNF-α (pg/ml), IL-6 (pg/ml), IFN-type I (pg/ml), IL-10 (pg/ml)and IL-1ra (pg/ml) | 3 months |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Cardiovascular parameters | 3 months | Aerobic capacity, chronotropic function |
| Muscle Strength | 3 months | Upper and Lower-body muscle strength will be assessed by a 1-RM (repetition maximum) protocol |
Countries
Brazil
Outcome results
None listed