A MRI Study of Visual and Motor Pathways in Premature Infants

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01514747

Enrollment

Registered

2012-01-23

Start date

2011-10-31

Completion date

2018-08-31

Last updated

2019-07-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Premature Birth

Brief summary

Approximately 30,000 babies annually are born with extremely low birth weight (ELBW) in the US. These babies often have motor and/or visual problems when they grow up. It is very important to identify high risk ELBW infants as early as possible, so that the investigators can treat them earlier to prevent poor development. Neurological examination at early age is not good enough to identify high risk ELBW infants. One the other hand, some magnetic resonance imaging (MRI) methods such as diffusion tensor imaging (DTI) and resting state functional MRI (rfMRI) have shown great sensitivity to brain injury which may cause motor and visual problems. Therefore, the investigators propose to use DTI and rfMRI on ELBW infants at a very early age to predict long-term outcome and to identify infants who are at high risk of having motor and/or visual problems when they grow up.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

2 Months to 5 Months

Healthy volunteers

Inclusion criteria

* ELBW infants with birth weight 401-1000 g (gestational age \<30 weeks)

Exclusion criteria

* Complex congenital anomalies * Central nervous system malformations, * Chromosomal abnormalities, or hydrops fetalis

Design outcomes

Primary

Measure	Time frame
MRI	0

Countries

United States

Outcome results