Analyzing the Composition of Tears and Blood for Discovery of Novel Signatures of Aggressive Prostate Cancer

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01514669

Enrollment

Registered

2012-01-23

Start date

2012-01-01

Completion date

2027-02-28

Last updated

2025-10-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Prostate Cancer

Brief summary

The purpose of this research study is to compare profiles in the blood and tears of patients with and without prostate cancer with the goal of developing a method of separating men with aggressive and non-aggressive disease.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

MALE

Age

35 Years to 85 Years

Healthy volunteers

Yes

Inclusion criteria

1. Male, 35-85 years old 2. Patients who present for the evaluation of an abnormal exam or test (elevated PSA, abnormal DRE, etc.) 3. Patients who present for the evaluation of a palpable nodule or induration on prostate exam 4. Patients who meet the requirements of Group 1, 2, or 3 of the protocol

Exclusion criteria

1. Patient \< 35 or \> 85 years of age 2. Concurrent eye infection or trauma, including active conjunctivitis 3. Abnormal production of tears (too much or too little) 4. Any other conditions the PI or staff feels will not fulfill the criteria for study entry or will place the subject in a harmful environment 5. Atypia on prostate biopsy report

Design outcomes

Primary

Measure	Time frame	Description
Tear Sample	1 day	Tear sample will be taken at the initial clinic visit

Countries

United States

Outcome results