Extracorporal Shockwave Lithotripsy Versus Retrograde Intrarenal Surgery for the Treatment of Kidney Stones

TOP-Stone: Treatment of Patients With Small Kidney Stones - Randomized Head-to-head Trial Comparing Extracorporal Shockwave Lithotripsy With Retrograde Intrarenal Surgery

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01514032

Enrollment

230

Registered

2012-01-20

Start date

2011-10-31

Completion date

2014-02-28

Last updated

2012-01-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Kidney Stones

Brief summary

The purpose of this study is to compare two established modalities for the treatment of kidneystones: ESWL (extracorporal shockwave-lithotripsy) vs. URS (uretero-reno-scopy with stone-extraction). Comparison of the stone-free rates 3month postoperative. * Trial with surgical intervention

Interventions

PROCEDUREExtracorporal shockwave lithotripsy

Extracorporal shockwave lithotripsy

PROCEDURERetrograde intrarenal surgery

Retrograde intrarenal surgery

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

- kidneystones requiring treatment up to an maximal size of 15mm (singular or multiple kidneystones with at least one stone with min. 5mm of size) * male and female patients between 18 and 99 years * informed consent signed by patient after explanation of the both treatment-modalities

Exclusion criteria

- age \< 18 or \> 99 * pregnancy * breastfeeding mother * disorders of blood clotting * kidneystones \> 15mm * aneurysms of the aorta or renal artery * severe skeletal deformations which hamper one of the treatment modalities * synchronous stones of the ipsilateral ureter * stones which can not visualized which X-ray or sonography

Design outcomes

Primary

Measure	Time frame
stonefree-rates 3month after therapy	3 month

Countries

Switzerland

Contacts

Primary ContactDamian Weber, MD

damian.weber@usz.ch+41 44 2555407

Backup ContactMichael Muentener, MD

michael.muentener@usz.ch+41 44 2555403

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026