Disuse Atrophy, Immobilization, Neuromuscular Electrical Stimulation
Conditions
Brief summary
In the present study, the effects of 5 days of lower limb immobilization with or without daily neuromuscular electrical stimulation on muscle mass and muscle fiber characteristics will be determined.
Interventions
BEHAVIORALimmobilization
Sponsors
Maastricht University Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
* Male * Aged from 18-35 years * 18.5 \< BMI \< 30 kg/m2
Exclusion criteria
* Smoking * Performing regular resistance training in the previous 6 months * Hypertension (according to WHO criteria) \[46\] and/or cardiovascular disease * Any back/leg/knee/shoulder complaints which may interfere with the use of crutches * Use of any prescribed medication * Type 2 diabetes mellitus * Any family history of thrombosis * All co-morbidities interacting with mobility and muscle metabolism of the lower limbs (e.g. arthritis, spasticity/rigidity, all neurological disorders and paralysis). * Myocardial infarction within the last 3 years * Use of anti-coagulants
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| muscle mass, muscle fiber size | three days before immobilization, and directly after immobilization (day of cast removal; day 6) |
Secondary
| Measure | Time frame |
|---|---|
| muscle strength measured by quadriceps 1-Repetition Maximum by Leg Extension | three days before immobilization, and directly after immobilization (day of cast removal; day 6) |
Countries
Netherlands
Outcome results
None listed