Avascular Necrosis of Hip, Total Hip Replacement Arthroplasty
Conditions
Brief summary
The investigators administered different kinds of colloids before transfusion of red blood cell to patient undergoing total hip replacement arthroplasty. The investigators will compare the differences of changes in rotational thromboelastometry (ROTEM) data among them.
Interventions
DRUGPentaspan, voluven, volulyte
Different colloids are administered during operation for replacement of blood loss before the transfusion of blood.
Sponsors
Seoul National University Bundang Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
20 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients diagnosed as avascular necrosis of hip and undergoing total hip replacement arthroplasty
Exclusion criteria
* hematologic disease * anticoagulant medication * preoperative hemoglobin \< 10 g/dl * renal disease * pulmonary disease (pulmonary edema, effusion) * cardiovascular disease (coronary heart disease, congestive heart failure)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| INTEM parameters change from preoperative values at post-operation | 30 minutes before operation and 30 minutes after operation | clotting time (sec), clot firmness time (sec), alpah angle, maximum clot firmness (mm) |
| EXTEM parameters change from preoperative values at post-operation | 30 minutes before and 30 minutes after operation. | clotting time (sec), clot firmness time (sec), alpah angle, maximum clot firmness (mm) |
| FIBTEM parameters change from preoperative values at post-operation | 30 min before and 30 min after operation | maximum clot firmness (mm) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Hematocrit | 30 minutes before operation and 30 minutes after operation | — |
| Platelet | 30 minutes before operation and 30 minutes after operation | — |
| Infused total fluid volume | Participants will be followed for the duration of THRA operation in operating room, an expected average tiem of 3 hours | crystalloid and colloid |
| Activated Partial Thrombin Time | 30 minutes before operation and 30 minutes after operation | — |
| electrolytes | 30 minutes before operation and 30 minutes after operation | — |
| Prothrombin Time-Internatiolnal Normalized Ratio | 30 minutes before operation and 30 minutes after operation | — |
| Hemoglobin | 30 minutes before operation and 30 minutes after operation | — |
| postoperative blood loss | postoperative 1 day and 2 day | — |
Countries
South Korea
Outcome results
None listed