Examining the Effectiveness of Combined Rehabilitation and Botulinum Toxin Injection on Functional Improvement of the Upper Limb After Stroke

Effectiveness of Botulinum Toxin Combined With Upper Limb Rehabilitation on Arm Function

Status

UNKNOWN

Phases

Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01511796

Enrollment

Registered

2012-01-19

Start date

2012-01-31

Completion date

2014-04-30

Last updated

2012-01-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Stroke

Keywords

stroke, upper limb rehabilitation function

Brief summary

The purpose of this study is to examine the effects of a combination of Botulinum Toxin (BT) and Upper Limb (UL) rehabilitation compared to BT only on UL motor function in adults with spasticity after stroke using a pre-post design. The research question is whether combination of BT and UL rehabilitation compared to BT only is more effective in improving the UL function, range of motion and pain.

Interventions

OTHERupper limb rehabiliation

3 months upper rehabilation (twice a week) and then 3 more months upper limb rehabitation ( twice a week)

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 75 Years

Healthy volunteers

Inclusion criteria

* over 18 years of age * at least 4 months post stroke * present with UL spasticity (MAS \>1 in elbow and/or spasticity of the hand, wrist or shoulder) * present with at lease a stage 3 of CMSA * able to comply with the requirements of the protocol and UL therapy programme.

Exclusion criteria

* significant cognitive and speech impairments * other upper limb impairments such as frozen shoulder * another diagnosis which could contribute to upper limb spasticity .

Design outcomes

Primary

Measure	Time frame
Modified Ashworth	up tp 2013

Secondary

Measure	Time frame
Goal attaiment Scale	up tp 2013

Countries

Canada

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026