Alcohol Abuse
Conditions
Keywords
Alcohol abuse
Brief summary
This is a multi-site study of adolescents 12-21 years-of-age to evaluate the long and shorter-term effect of adolescent alcohol use on the developing brain.
Detailed description
The overall specific aims of this study are to: 1) assess the short and long-term consequences of alcohol exposure on brain, cognitive, and emotional/regulatory development during preadolescence and adolescence; 2) determine the effects of timing, dose, and duration of alcohol on brain and cognitive development; 3) assess recovery of neural and behavioral function to determine if the plasticity of the adolescent brain makes it more or less vulnerable to alcohol's acute and chronic effects; 4) understand how other key covariates (e.g., existing or emerging psychopathology, family history of alcoholism, demographics, pubertal development) factor into alcohol's effects on the brain; and 5) identify early neural, cognitive, and affective markers that may predict alcohol abuse and dependence during adolescence and/or adulthood.
Interventions
None listed
Sponsors
Massachusetts General Hospital
Mclean Hospital
Massachusetts Institute of Technology
Boston Children's Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
12 Years to 21 Years
Healthy volunteers
No
Inclusion criteria
* able to read and understand English * available for follow-up * parental consent/adolescent assent for those 12-17 years * consent for those 18-21 years
Exclusion criteria
* Weight \> 300 lbs * braces or unremovable embedded metal * claustrophobia or inability to lie still in MRI machine * current or past 12-mos pregnancy (females) * requires urgent medical/mental health care
Countries
United States
Outcome results
None listed