Endothelial Function of Saphenous Vein Grafts
Conditions
Keywords
endoscopic vein harvest, saphenous vein graft, endothelial function
Brief summary
This is a single center prospective study of 30 patients undergoing elective heart bypass surgery (CABG) with at least two vein grafts from the leg (SVG). The purpose of this ex vivo study is to evaluate the function of vein grafts from small tissue samples treated with a pressure syringe and a non-pressure syringe. Syringes are routinely used to flush out the veins in preparation of bypass grafting. It is unknown if different levels of pressure in the syringe affect the vein or damage the vein. Small sections of tissue samples which are normally discarded will be obtained immediately after retrieval from the leg and before grafting to the heart. Tissue samples will be taken to the laboratory for study. There are no clinical endpoints in this study, however, clinical information will be obtained from the Society of Thoracic Surgeons database and will include demographics, risk factors, and perioperative outcomes.
Interventions
OTHERUse of Maquet Vasoshield Pressure-limiting syringe on SVG
Use of Maquet Vasoshield Pressure-limiting syringe on SVG
OTHERUse of non-regulated syringe on SVG
Use of non-regulated syringe on SVG
Sponsors
Maquet Cardiovascular
Emory University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
21 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* patients undergoing elective coronary artery bypass graft surgery requiring at least 2 saphenous vein grafts
Exclusion criteria
* patients undergoing any concomitant surgical procedures
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| SVG vascular contractility | Day of surgery |
Secondary
| Measure | Time frame |
|---|---|
| Nitric oxide metabolite levels | Day of surgery |
| Major adverse cardiac events | 6 months and 1 year |
Countries
United States
Outcome results
None listed