Azoospermia, Insulin Resistance, Oligospermia
Conditions
Keywords
insulin resistance, unexplained azoospermia, unexplained oligospermia
Brief summary
Insulin resistance in men can be the underlying major factor in reproductive abnormalities ( chronic hypospermatogenesis ) as well as metabolic abnormalities similar to polycystic ovarian syndrome ( PCOS ) in women.
Detailed description
During the past decade IR has been recognized as a major contributor to the pathogenesis of chronic anovulation, hyperandrogenism and metabolic abnormalities associated with PCOS . Theoretically IR in men may result in a similar reproductive abnormalities ( chronic hypospermatogenesis ) as well as other metabolic abnormalities similar to what happens in PCOS in women .
Interventions
OTHERblood samples
blood samples to test for primary and secondary outcome measures
OTHERBlood samples
IR Cholesterol HDL LDL Fasting Glucose Triglycerides
Sponsors
The Egyptian IVF-ET Center
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
25 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
* sperm count less than 10 million per milliliter * non-obstructive azoospermia
Exclusion criteria
* high FSH ( \> 10 mIU/ ml ) * high prolactin ( \> 36 mIU/ml ) * abnormal karyotype * AZF
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| serum insulin | one month |
Secondary
| Measure | Time frame |
|---|---|
| cholesterol | one month |
| high density lipoprotein ( HDL) | one month |
| Fasting Glucose | one month |
| testosterone | one month |
| Triglycerides | One month |
| Low density lipoprotein ( LDL ) | one month |
Countries
Egypt
Outcome results
None listed