Vitamin D Inadequacy is Associated With Incidence of Type 2 Diabetes

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01508481

Enrollment

1500

Registered

2012-01-12

Start date

2007-01-31

Completion date

2012-10-31

Last updated

2012-10-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type 2 Diabetes

Keywords

Vitamin D, Diabetes, pancreas beta cell function, insulin resistance, Deficiency of Vitamin D3

Brief summary

Emerging evidence suggests that vitamin D \[25-hydroxyvitamin D; 25(OH)D\] may play a role in the etiology of type 2 diabetes. Vitamin D levels are lower in those with type 2 diabetes and impaired glucose tolerance (IGT) compared with those with normal glucose tolerance (NGT). In addition, a few prospective studies have shown a significant inverse association of baseline serum 25(OH)D with incident diabetes. To date, however, the exact mechanisms through which vitamin D affects diabetes risk are not yet fully known, particularly whether vitamin D plays a role in insulin resistance (IR) and/or b-cell dysfunction, the main pathophysiological disorders underlying type 2 diabetes. So, the investigators plan to examine the prospective associations of baseline vitamin D \[25-hydroxyvitamin D; 25(OH)D\] with insulin resistance (IR), b-cell function, and glucose homeostasis in subjects at risk for type 2 diabetes.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

30 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* one or more risk factors for diabetes, including: * obesity * hypertension * dislipidemia * a family history of diabetes

Exclusion criteria

* previous diagnosed diabetes * vitamin D supplement.

Design outcomes

Primary

Measure	Time frame	Description
Incidence of diabetes	5 years	Incidence of diabetes defined by American Diabetes Association criteria

Secondary

Measure	Time frame	Description
Pancreatic beta cell function	5 years	Pancreatic beta cell function assessed by homeostasis model
Insulin resistance	5 years	Insulin resistance assessed by homeostasis model

Countries

South Korea

Outcome results