Comparitive Study of Two Misoprostol Regimen in Early Pregnancy Termination

A Comparative Study of Vaginal Misoprostol Two Dosing Regimen for First Trimester Pregnancy Termination in Patients Admitted at Bandarabbas in Shariati Hospital in 2009

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01508143

Enrollment

Registered

2012-01-11

Start date

2012-01-31

Completion date

2012-09-30

Last updated

2012-10-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Termination

Keywords

Abortion, Pregnancy, Termination, Misoprostol

Brief summary

The aim of this study is to compare two misoprostol regimen in pregnancy termination.

Detailed description

Studies on determining the optimal dosage for misoprostol in pregnancy termination are continuing and still there is no evidence for ideal misoprostol regimen for pregnancy termination. The aim of this study is to compare two misoprostol regimen in pregnancy termination.

Interventions

DRUGMisoprostol 400 micrograms

Misoprostol 400 micrograms each 6 hours for 8 dose

DRUGMisoprostol 800 micrograms

Misoprostol 800 micrograms each 12 hours for 4 doses

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

FEMALE

Healthy volunteers

Inclusion criteria

* All women who were candidates for early pregnancy termination because of fetal death or other medical conditions * Before 14th week of gestation calculated according LMP or first trimester sonography

Exclusion criteria

* Chorioamnionitis * Hypersensitivity to prosstaglandins * Past medical history of cardiovascular, kidney or liver or lung diseases * Positive history for uterus pathologies * suspicious to extra-uterus pregnancy * sign and symptoms of uterus infection * Molar pregnancy

Design outcomes

Primary

Measure	Time frame	Description
Abortion	48 hours after treatment	After 48 hours after treatment each patient is assessed for abortion. Patients are devided into three groups including complete, partial or no abortion.

Secondary

Measure	Time frame	Description
Duration of abortion	Form the begining of treatment to complete abortion	Duration of abortion Form the begining of treatment to complete abortion
Adverse Effects	48 hours after treatment	including nausea, vomiting, fever and chill, diarhea, abdominal cramp, skin rash
Need for surgery	48 hours after treatment	Dilatation & cartage

Countries

Iran

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026