Chronic Obstructive Pulmonary Disease
Conditions
Keywords
COPD, CPAP, Sham, FEV1, IC, RV/TLC
Brief summary
Chronic obstructive pulmonary disease is a disease characterized by small airways inflammation and obstruction. The small airways disease produces hyperinflation (air trapping), which increases with exercise. Continuous positive airways pressure may reduce small airways obstruction and therefore air trapping. Pulmonary function tests including lung volumes at rest and and after exercise will be measured. In addition, exercise endurance time before treatment and after treatment will be measured.
Detailed description
Continuous positive airways pressure which prevent small air ways collapse and may also clear secretions. At first stage the optimal pressure for reducing air trapping will be determined. In addition, all patients will undergo a maximal exercise test. A baseline complete pulmonary function test is performed followed by continuous positive air way pressure at the pre-determined pressure. This will be followed by exercise at 60% of maximal obtained previously.
Interventions
DEVICEpositive ventilation
10 minutes of increased 4,7,12 positive pressure ventilation
Sponsors
Assaf-Harofeh Medical Center
Study design
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
45 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* chronic obstructive lung disease stage 2-3 GOLD * FRC \> 120%
Exclusion criteria
* active ischemic heart disease * heart failure * peripheral vascular disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| improved small airways obstruction | 2-3 hrs | Following CPAP ventilation measurement be repeated for 3 hrs |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| improved respiratory symptoms | 2-3 hrs | CAT score |
Countries
Israel
Outcome results
None listed