The Effect of Hinge Location on Corneal Sensation and Dry Eye After LASIK: A Systematic Review and Meta-analysis

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01507025

Enrollment

400

Registered

2012-01-10

Start date

2011-10-31

Completion date

2014-02-28

Last updated

2014-02-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dry Eye

Keywords

hinge position, dry eye

Brief summary

The purpose of this study is to investigate the possible effect of hinge location on corneal sensation and dry eye syndrome after laser in situ keratomileusis (LASIK).

Detailed description

Dry eye symptoms are a frequent postoperative complication of laser in situ keratomileusis (LASIK). Although estimates of the incidence of dry eye syndrome vary widely, from 3% to 59%, almost all patients will have transient dry eye during the immediate postoperative period.Because of the variability in corneal innervation patterns, altering flap characteristics in LASIK may affect postoperative corneal sensation and dry-eye disease. Some studies have reported that postoperative corneal sensation may be higher and recovery faster in eyes with horizontal flaps (nasal- or temporal-hinge) than in eyes with vertical flaps (superior- hinge). However, some other studies have not established an association between corneal sensation and hinge position. This study reviewed the published literature and performed a meta-analysis aimed to investigate the effects of hinge location on corneal sensation and dry-eye symptoms after LASIK.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 60 Years

Healthy volunteers

Inclusion criteria

1. each trial should be a prospective randomized controlled clinical trial (RCT), 2. the age of patient population should be over 18 years

Exclusion criteria

1. non-randomized controlled trials 2. patients who had had a previous ophthalmic surgery or ocular surface disorders 3. the raw data was not completed

Design outcomes

Primary

Measure	Time frame	Description
Corneal sensitivity	6 months	Change of corneal sensitivity by using the Cochet-Bonnet esthesiometer,we chose to analyze results at 1 week and 1-, 3-, 6-month postoperatively.
Tear break-up time	6 months	Change of tear break-up time at 1 week and 1-, 3-, 6-month postoperatively
Schirmer's I test	6 months	Change of Schirmer's I score at 1 week and 1-, 3-, 6-month postoperatively

Secondary

Measure	Time frame
Corneal fluorescein staining	6 months

Countries

China

Outcome results