Feeding Patterns, Bone Resorption
Conditions
Keywords
feeding patterns, aerobic exercise, osteoclasts
Brief summary
This study examined changes in bone metabolism (markers of bone turnover, calcium metabolism) with a bout of acute treadmill running preceded by either a single, mixed meal or an overnight fast.
Detailed description
Ten physically active males aged 28 ± 4 y (mean ± 1SD) completed two, counterbalanced, 8 d trials. After 3 d on a standardised diet, participants performed 60 min of treadmill running at 65% VO2max on Day 4 following an overnight fast (FAST) or a standardised breakfast (FED). Blood samples were collected at baseline, before exercise, during exercise, for 3h after exercise and on four consecutive follow-up days (FU1-FU4). Plasma/serum were analysed for β CTX, P1NP, OC, bone ALP, PTH, ACa, PO4, OPG, cortisol, leptin and ghrelin.
Interventions
OTHEROvernight fast
Overnight fast from 21:00 h
Sponsors
Ministry of Defence, United Kingdom
QinetiQ Ltd
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* history of weight bearing exercise * fasting vitamin D concentration of \>30 nmol•L-1 and/or a fasting parathyroid hormone (PTH) concentration of \<6.9 pmol•L-1.
Exclusion criteria
* smokers * suffered a bone fracture in the previous 12 months * musculoskeletal injury * condition/medication known to affect bone metabolism
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in C-terminal telopeptide region of collagen type 1 (B-CTX) concentration from baseline | At 08:00 h (Baseline), 09:00 h, 09:30 h, and 10:15 h (Pre-exercise), after 30 and 60 min of exercise, after 1, 2, and 3 h of recovery and at 1, 2, 3 and 4 day post-exercise | B-CTX is a specific marker of bone resorption. It's circulating concentration is altered by both exercise and feeding |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in parathyroid hormone (PTH) concentration from baseline | At 08:00 h (Baseline), 09:00 h, 09:30 h, and 10:15 h (Pre-exercise), after 30 and 60 min of exercise, after 1, 2, and 3 h of recovery and at 1, 2, 3 and 4 day post-exercise | PTH is reported to induce both bone resorption and bone formation. It's circulating concentration is altered by both exercise and feeding. |
Countries
United Kingdom
Outcome results
None listed