Aortic Valve Stenosis
Conditions
Keywords
Exercise, Physical Activity, Physiotherapy, Exercise test, Quality of Life, Aortic Valve Replacement
Brief summary
SURVEY OF THE FIELD Aortic stenosis (AS) is the most common valve disease and increasing due to a growing elderly population. The therapy is aortic valve replacement (AVR). Studies on postoperative rehabilitation of AS pts are scarce. In the few studies available, a mix of valve diseases is presented without considering the differences in pathophysiology and the training regimes are not clearly described. PURPOSE, AIMS & HYPOTHESIS The investigators purpose is to evaluate whether a supervised cardiac rehabilitation program improves the objective physical capacity and quality of life (QoL) of patients after AVR due to AS, and compare this to patients training by their own. The investigators hypothesize that supervised exercise training may be a more efficient way of rehabilitating these patients. DESIGN This is a controlled randomized clinical trial comparing 12 weeks of supervised exercise training 3 times per week to home-based training based upon public health recommendations of minimum level of physical activity. SIGNIFICANCE & IMPLEMENTATION Positive results would support that an organized program of exercise training improves physical capacity and QoL in AS patients following AVR with potential benefit for both patients and society.
Interventions
OTHERAerobic Exercise Training
12 weeks of endurance training, 40 minutes, 3 times per week on ergometer bicycle.
Written and verbal information on minimal level of physical activity recommended.
Sponsors
Linkoeping University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Elective surgery with aortic valve replacement for aortic stenosis at the thoracic surgery department at Linköping University hospital, Linköping. * Geographical residence no further from hospital than permitting visit to Supervised Exercise Training 3 times per week
Exclusion criteria
* Any concommitant heart disease * Other surgical intervention at time of valve replacement * Age under 18 years * Symptomatic lung disease * Any disability or disease hampering participation in exercise training * Cannot communicate with spoken Swedish
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in peak oxygen uptake | Before (within one week before intervention), 1 week after and 12 months after intervention | Physical capacity measured with cardiopulmonary exercise testing (CPET) on bicycle ergometer. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in Health-related Quality of Life | Before (within one week before intervention), 1 week after and 12 months after intervention | Short-form 36, version 2 |
| Change in Physical activity level | Before (within one week before intervention), 1 week after and 12 months after intervention | PAL - Physical activity level, measured with International Physical Activity Questionnary (IPAQ) |
| Change in hs-CRP | Before (within one week before intervention), 1 week after and 12 months after intervention | — |
| Change in NT-pro-BNP | Before (within one week before intervention), 1 week after and 12 months after intervention | — |
Countries
Sweden
Outcome results
None listed