Corneal Endothelial Changes Following Pediatric Cataract Surgery With IOL Implantation

Corneal Endothelial Morphologic Assessment in Pediatric Cataract Surgery With IOL Implantation: Comparison of Preoperative and Early Postoperative Specular Microscopy

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01504607

Enrollment

106

Registered

2012-01-05

Start date

2011-01-31

Completion date

2011-10-31

Last updated

2012-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Change in Corneal Endothelial Cell Morphology, Congenital Cataract Surgery, IOL Implantation

Keywords

corneal endothelium, congenital cataract surgery, IOL implantation

Brief summary

Cataract surgery is known to cause loss of corneal endothelial cells. In adults, it is reported that anywhere between 2 to 15% loss of corneal endothelial cell density occurs following cataract surgery. However, no data is available regarding endothelial changes after cataract surgery with IOL implantation in pediatric eyes. The aim of this study is to prospectively observe changes in endothelial cell density, coefficient of variation and hexagonality following cataract surgery with IOL implantation in pediatric eyes.

Interventions

PROCEDURECongenital Cataract Surgery

Congenital cataract surgery with IOL implantation

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

4 Years to 15 Years

Healthy volunteers

Inclusion criteria

* Eyes undergoing pediatric cataract surgery with IOL implantation at Iladevi Cataract & IOL Research Center, Ahmedabad, India. * Children older than 4 years undergoing cataract surgery with IOL implantation were included.

Exclusion criteria

Design outcomes

Primary

Measure	Time frame	Description
Corneal endothelial morphology	preoperatively to 3 months postoperatively	Change in corneal endothelial cell density, (CD), coefficient of variation (CV) and % of hexagonality (6A) were studied from preoperatively to 3 months postoperatively

Secondary

Measure	Time frame	Description
Change in central corneal thickness	preoperatively to 3 months postoperatively	Change in central corneal thickness from preop to 3 months postop was studied

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026