Chinese Herb Nephropathy Epidemiology and Association With CYP2D6, CYP2C19, PXR, or MDR1 Polymorphism

Epidemiology of Chinese Herb Nephropathy and Its Association With CYP2D6, CYP2C19, PXR, or MDR1 Polymorphism

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01503645

Enrollment

200

Registered

2012-01-04

Start date

2006-05-31

Completion date

Unknown

Last updated

2012-11-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Kidney Diseases

Keywords

kidney diseases, drugs, Chinese herbal, aristolochic acid, polymorphism, genetic

Brief summary

1. Chinese herb nephropathy (CHN), a kind of kidney failure caused by Chinese herbs, may be related to the a component called aristolochic acid (AA). 2. AA may form AA-DNA adducts and accumulate in the kidney and ureter and cause kidney failure and/or cancer 3. Different enzymes have been reported to detoxify plant alkaloids or other components. Genes that regulate the production of these metabolic enzymes may affect the chance of CHN. 4. By comparing the differences in the polymorphisms of these genes between patient with CHN and control, we may find the changes that play a significant genetic factors for CHN.

Interventions

None listed

Study design

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Healthy volunteers

Yes

Inclusion criteria

* Patient with suspected Chinese herb nephropathy, and their family Control group match for sex age and geographic area (with or without herabla use)

Countries

Taiwan

Contacts

Primary ContactFe-Lin L Wu, Ph.D.

flwu@ha.mc.ntu.edu.tw+886-2-23938231

Backup ContactKwan-Dun Wu, MD, Ph.D.

kdw@ntumc.org+886-2-23123456

Outcome results