Antimuscarinic Drug
Conditions
Brief summary
Overactive bladder syndrome (OAB) affects around 17 % of female population. However, the etiology of OAB was complicated and unclear in many aspects. In particular, the research about psychiatric aspect of etiology in OAB was paucity. Besides, research about prognostic factors and impact of cardiovascular system of OAB treatment was also paucity. Therefore the aims of the investigators study were (1) to analyze the etiology of OAB in psychiatric aspects; (2) to analyze the prognostic factors associated with tolterodine treatment; (3) to analyze the differences of cardiac conduction and heart rate variability before and after tolterodine treatment; (4) to analyze the differences of arterial stiffness between non-OAB and OAB female patients, and before and after tolterodine treatment.
Interventions
DRUGtolterodine, solifenacin
The enrolled women before March 2009 were treated with tolterodine 4 mg slow-release, and after March 2009 were treated with solifenacin 5 mg once a day for 12 weeks.
Sponsors
National Taiwan University Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* all cases are female patients with lower urinary tract symptoms
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes of heart rate variability after antimuscarinics | 3 months | Changes of heart rate variability after 3-months' antimuscarinics treatment |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Changes of arterial stiffness after antimuscarinics treatment | 3 months | Changes of arterial stiffness after 3-months antimuscarinics' treatment |
| Changes of psychologic distress after antimuscarinics treatment | 3 months | Changes of psychologic distress after 3-months' antimuscarinics treatment |
Countries
Taiwan
Outcome results
None listed