Deficiency of Vitamin D3, Hypertensive Disease
Conditions
Brief summary
The aim of this study is to investigate whether a supplementation of Vitamin D3 can be used to reduce atherosclerotic risk factors.
Detailed description
It is the objective of this study to investigate whether a supplementation with Vitamin D3 can be used to reduce atherosclerotic risk factors such as hypertension, inflammation and hyperlipidemia. The research question is whether Vitamin D3 can lower blood pressure in mildly hypertensive subjects who are naive to antihypertensive medication, whether Vitamin D reduces the level of systemic inflammation and whether Vitamin D3 has an effect on blood lipids. major outcomes: \- decrease of systolic blood pressure in the treatment group in comparison with the placebo group
Interventions
DIETARY_SUPPLEMENTVitamin D3
daily dosage of 50 µg Vitamin D3 for 8 weeks
DIETARY_SUPPLEMENTPlacebo
daily intake of placebo
Sponsors
German Federal Ministry of Education and Research
Martin-Luther-Universität Halle-Wittenberg
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* human volunteers with mild hypertension
Exclusion criteria
* use of antihypertensive medication * use of vitamin d or calcium supplements * known renal, inflammatory or malignant diseases * hypercalcemia or hypercalciuria * participation in other clinical studies * use of tanning booths during the study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| blood pressure | after 8 weeks of supplementation | major outcome variable is the decrease oy systolic blood pressure in the treatment group in comparison with the placebo group. |
Outcome results
None listed