Burns, Sepsis
Conditions
Brief summary
The purpose of this study is to determine if early application of CRRT will result in an improvement of clinical outcomes of burn patients during the early phase of sepsis
Detailed description
The impact of Continuous Renal Replacement Therapy (CRRT) on the outcomes of patients with sepsis is controversial, and there is no consensus for the timing and dose of CRRT may improve the outcomes. The purpose of this prospective randomized study is to assess the effect of different CRRT intensity (25ml/kg/h or 50ml/kg/h) on the outcomes of burn patients with early phase of sepsis
Interventions
PROCEDUREContinuous Renal Replacement Therapy
Patients will be randomized to either arm :early HV-crrt(50ml/kg/h) or Control group
Sponsors
Southwest Hospital, China
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* patients with documented sepsis * clinically identified focus of infection associated with at least 2 SIRS -criteria and one or more sepsis-induced organ failures within the 24 hours -prior to inclusion * age 18 to 70 years * severe burned patients with 50% \< TBSA \< 85%
Exclusion criteria
* cirrhosis child class C * too high APACHE II & SOFA score at admission * age over 70 years * were presence of a malignant tumor, chronic renal insufficiency (serum creatinine \> 133 µmol/L), moribund state, receiving immunosuppressive therapy or receiving any kind of renal replacement therapy before randomization
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes in serum cytokine concentrations and clearance | 96 hours | 0, 6, 12 , 24, 48, 96 hours post CRRT |
Secondary
| Measure | Time frame |
|---|---|
| 28 and 90 days survival | 90 days |
Countries
China
Outcome results
None listed