Liver Cirrhosis
Conditions
Keywords
liver cirrhosis, autologous mesenchymal stem cell transplantation
Brief summary
This study is aiming to investigate the efficacy of autologous mesenchymal stem cell (MSC) transplantation in 25 randomized patients with liver cirrhosis autologous mesenchymal stem cell will be derived from patients' bone marrows and will be infused via peripheral vein. Liver biopsies will be performed in every patient in the beginning and at 6th month.
Interventions
Every patient is given 1x106 MSCs per kg infused via peripheral vein.
Sponsors
Saglik Bilimleri Universitesi Gulhane Tip Fakultesi
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* radiological, clinical and histopathological diagnosis of liver cirrhosis * absence of hepatocellular carcinoma or any malignancies * no psychiatric disorder * no serous cardiovascular and pulmonary comorbidities * serum total bilirubin levels less than 5 mg/dL * platelet counts more than 30.000 mm3 * more than one year follow up period after initiation of antiviral drugs
Exclusion criteria
* alcohol intake in last one year * initiation of antiviral medication in last one year * systemic diseases
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| clinical improvement | clinical improvement parameters will be assessed six month after mesenchymal stem cell transplantation | biochemical and hematologic parameters |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| liver regeneration | 6.th month after MSC transplantation | histopathologic assesments comparing before and at 6th month liver biopsies |
Countries
Turkey (Türkiye)
Outcome results
None listed