Lung Cancer, Lung Lobectomy
Conditions
Brief summary
The purpose of this study is to investigate effect of increasing inspiratory time (I:E ratio 1:1) on intrapulmonary shunt fraction and oxygenation during one lung ventilation in the lateral decubitus position.
Detailed description
Increasing inspiratory time(e.g. Inverse ratio ventilation) has been known that had advantage of alveolar recruitment, preventing of ateletasis. On the contrary, it has disadvantange of intrinsic PEEP, air trapping. There is few study on one lung ventilation in lateral decubitus position about this ventilation method. We were going to investigate effecf of this ventilation method.
Interventions
PROCEDUREI:E ratio
I:E ratio 1:1 Volume controlled ventilation TV:8ml/kg EtCO2:35-40mmHg
Sponsors
Yonsei University
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
40 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* ASA physical status class I, II * Use of Double lumen tube * Unilateral lung lobectomy
Exclusion criteria
* COPD * CAOD * Unstable hemodynamic status * Peak airway pressure \> 30mmHg (Two lung ventilation)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| intrapulmonary shunt fraction | T1 (10min before one lung ventibation)T2 (30min after one lung ventilation started)T3 (60min after one lung ventilation started)T4 (10min after two lung ventilation) | T1,T2,T3,T4 : ALL mesurement in lateral decubitus position T1-intrapulmonary shunt T2-intrapulmonary shunt T3-intrapulmonary shunt T4-intrapulmonary shunt |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Respiratory dynamic parameters | T1,T2,T3,T4 (same as primary outcome measure) | Mechanical Ventilator measurement : Paw, Pplat, Pmean, Compliance |
Countries
South Korea
Outcome results
None listed