Healthy
Conditions
Keywords
volunteer
Brief summary
Intra-epidermal nerve fiber density can be assessed using skin biopsy. A decrease of this density is used to diagnose small fiber neuropathy, despite the absence of normative data in a selected normal population. To establish a normative set of data matched for age and sex is absolutely needed to evaluate the sensibility and specificity of this test.
Interventions
PROCEDUREBiopsy
3 mm punch biopsy of the skin at the distal leg.
Sponsors
University Hospital, Strasbourg, France
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
20 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* Man or woman between 20-80 years old * Normal subjects without pain and neurological impairment * No history of neurological disorder * Normal neurological examination * Normal ECG * Normal clotting sample from less than 6 months * Available by phone
Exclusion criteria
: * History of alcoholic intoxication or chemotherapy * History of diabetes, kidney insufficiency, monoclonal gammapathy, B/C hepatitis, HIV, coeliac disease, sicca syndrome, raynaud syndrome, systemic erythematous lupus, Fabry disease, amylosis, vascularitis * Contraindication to xylocaïn with adrenalin * At the site of biopsy : surgery, skin pathology, infection, vascular insufficiency * Innate or acquired immunosuppression * Innate or acquired clotting abnormality
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Measure density of intraepidermic nervous fibres by optical and electronic microscopy in a population of healthy witnesses according to the age and the sex. | 1 month |
Countries
France
Outcome results
None listed