Post-Infectious Irritable Bowel Syndrome (PI-IBS)

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01497847

Acronym

PI-IBS

Enrollment

131

Registered

2011-12-23

Start date

2010-03-31

Completion date

2013-02-28

Last updated

2013-04-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Irritable Bowel Syndrome With Diarrhea

Keywords

Post-Infectious Irritable Bowel Syndrome, PI-IBS

Brief summary

Purpose: * identification of factors predisposing for Post-Infectious Irritable Bowel Syndrome (PI-IBS) development after an episode of traveler's diarrhea * identification of systemic (serum) and local (biopsy) changes in infectious and immunological activity during infection and correlation with Irritable Bowel Syndrome (IBS) symptoms, persisting after traveler's diarrhea Design: * 4 study visits: before traveling, 2 weeks after traveling, 6 months after traveling, 12 months after traveling * at each study visit following investigations: blood collection, stool collection, questionnaires, rectal biopsy

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 70 Years

Healthy volunteers

Yes

Inclusion criteria

* traveling to South-America, Africa, South-East Asia * 18-70 years * traveling for 1-10 weeks

Exclusion criteria

* Chronic diarrhea * Pregnant * Colitis Ulcerosa * Morbus Chrohn * IBS * Coeliakie * Gastrointestinal malabsorption * microscopic colitis * diverticulitis * immune deficiency * use of antibiotics/corticosteroids 2 weeks before travelling

Design outcomes

Primary

Measure	Time frame
postinfectious IBS symptoms (ROME III criteria) 1 year after travelers diarrhea episode	1 year after traveling

Countries

Belgium

Outcome results