Hemoptisis
Conditions
Keywords
hemoptisis, bleeding, tranexamic acid
Brief summary
Hemoptysis is defined as the expectoration of blood from respiratory tract, a spectrum that varies from blood-streaking of sputum to coughing up large amounts of pure blood. Massive hemoptysis variably defined as the expectoration of 100-600 ml over 24-h period. The most common site of bleeding is the tracheobronchial tree, which can be affected by inflammation (acute or chronic bronchitis, bronchiectasis) or by neoplasm ( bronchogenic carcinoma, endobronchial metastatic carcinoma, bronchial carcinoid tumor). The bronchial arteries, which originate either from aorta or from intercostal arteries, and are part of the high-pressure systemic circulation, are the source of bleeding in bronchitis or bronchiectasis or endo bronchial tumors.
Interventions
DRUGtranexamic acid
500 mg/5 ml 3-4 times a day
Sponsors
Meir Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* Age \> 18 * Hemodynamicaly stable * Hemoptysis of varying etiologies * Coumadin treatment will be switched to clexane or heparine
Exclusion criteria
* Age \< 18 * Hemodinamicaly unstable * Massive hemoptysis ( \> 200 ml / day) * Renal failure: creatinine \> 3, renal replacement treatment * Hepatic failure: bilirubin \> 2 mg/dl, AST \> 3 of upper normal limit level * Coagulation disorders, INR\> 2. * Hypesensitivity to tranexamic acid * Pregnant woman
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| bleeding stops | 1 year |
Countries
Israel
Contacts
Primary ContactDavid Shitrit, Dr.
Outcome results
None listed