Osteoarthritis
Conditions
Brief summary
Osteoarthritis is by far the most common joint condition and the single largest cause of disability in the older population. The investigators still have a poor understanding of the nature of osteoarthritis and factors that influence its development and progression. Identification of biochemical markers that relate to cartilage loss, bony overgrowth and other features that occur with osteoarthritis will advance our understanding. Over the last 5 years analytical methods have developed to measure a range of different biomarkers. This pilot study will use these analytical methods to measure biomarker levels in joint fluid, urine and blood of 50 participants with Osteoarthritis (OA) and 50 healthy volunteers. This study will provide novel pilot data on the changes in the composition of the synovial fluid, urine and blood in patients with OA. Apart from being a key target site for OA, the knee is a suitable joint for study because of its accessibility to clinical assessment, joint aspiration and imaging.
Interventions
None listed
Sponsors
University of Nottingham
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
30 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
All participants: * Be able to provide written informed consent * Aged 30 and over Knee OA patients: • Radiographic signs of OA - that is definite joint space narrowing plus osteophyte in at least one compartment of the knee Normal controls: * No knee pain * No clinical or radiographic changes of knee OA
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Difference in the levels of pro-inflammatory and anti-inflammatory lipids mediators between individuals with knee osteoarthritis and those with normal knees. | within 6 months of recruitment of last participant |
Countries
United Kingdom
Outcome results
None listed