Peripherally Inserted Versus Centrally Inserted Central Venous Catheters in the Neurological Intensive Care

A Phase III Study of Peripherally Inserted Versus Centrally Inserted Central Venous Catheters in the Neurological Intensive Care Unit

Status

Completed

Phases

Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01495429

Acronym

PICNIC

Enrollment

Registered

2011-12-20

Start date

2012-01-31

Completion date

2015-07-31

Last updated

2015-08-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Venous Thrombosis

Keywords

catheter related large vein thrombosis, upper extremity deep venous thrombosis, central venous catheters, upper extremity catheter related large vein thrombosis

Brief summary

The investigators aim to compare the complications between centrally and peripherally inserted central venous catheters in neurological intensive care unit patients. The study hypothesis is that peripherally inserted catheters will have more cumulative complications due to venous thrombosis.

Interventions

PROCEDURECentral venous catheter

Placement of a peripherally inserted central venous catheter

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* all patients age \> 18, admitted to the neurological ICU who are require a de novo central venous catheter as standard of care and in which a double lumen 5f PICC or CICVC (triple lumen, 7f) are acceptable for the indication. * the patients must be expected to survive and need a central venous catheter for at least 7 days.

Exclusion criteria

* prisoner * age \< 18 * expected to die or have care withdrawn prior to ICU day 7 * requiring an emergent central venous catheter * suspected bacteremia * recent central venous catheter within the last 30 days * patients who are not a candidate for bedside placement of either a CICVC or PICC line * patients with renal insufficiency with creatinine level greater than 3.0 mg/dL (265.2 m mol/L) or who were undergoing hemodialysis * patients requiring a central venous catheter for prolonged antibiotic therapy\\ * patient who the treating clinician feels clearly needs one particular type of catheter over the other

Design outcomes

Primary

Measure	Time frame
The composite of death or catheter related large vein thrombosis	15 days

Secondary

Measure	Time frame
Cumulative catheter related complications until discharge	30 days

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026