Trauma
Conditions
Keywords
Glucose, Lactate pyruvate ratio, Glycerol, Paraspinal muscle, Microdialysis
Brief summary
Paraspinal muscle damage is inevitable during conventional posterior lumbar fusion surgery. Minimal invasive surgery is postulated to result in less muscle damage and better outcome. The aim of this study is to monitor metabolic changes of the paraspinal muscle and to evaluate paraspinal muscle damage during surgery using microdialysis (MD).
Detailed description
Posterior approach is a common and important surgical procedure for various lumbar diseases. Owing to the anatomy, the damage of paraspinal muscle is inevitable during conventional posterior lumbar fusion surgery. Degeneration and malfunction of the paraspinal muscle might associate with pain and inferior postoperative clinical outcome.
Interventions
PROCEDUREPosterolateral lumbar fusion surgery
Two MD catheters with 1% lidocaine 1-2 ml are placed in the paraspinal muscle.
Sponsors
Northern Orthopaedic Division, Denmark
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* patients who undergo conventional instrumented posterolateral lumbar fusion.
Exclusion criteria
* previous fusion * chronic metabolic disease * tumor or metastasis * postoperative surgical complications and complications during surgery
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The glycerol concentration | Two hours | To study whether the glucerol concentration can be used to evaluate surgery related paraspinal muscle damage |
Outcome results
None listed