Sepsis, SIRS(Systemic Inflammatory Response Syndrome)
Conditions
Keywords
CD4+T lymphocyte subsets, sepsis, immunoparalysis
Brief summary
The purpose of this study is to explore the value of CD4+T lymphocyte subsets in cell immunity in the patients with sepsis.There are immunoparalysis in septic patients,the important player is the change of CD4+T lymphocyte,this immunoparalysis state contribute to the illness progress and outcome. Comprehend the change regularity of septic patients' cell immunity can guide fiter and correcter treatment.
Interventions
None listed
Sponsors
Chinese PLA General Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Male and female aged 18 years old and over; * Fulfilled at least two criteria of systemic inflammatory response syndrome (a) core temperature higher than 38 °C or lower than 36 °C (b)respiratory rate above 20/min, or PCO2 below 32 mmHg (c) pulse rate above 90/min, and (d) white blood cell count greater than 12,000/μl or lower than \< 4,000/μl or less than 10% of bands. * Clinically suspected infection;
Exclusion criteria
* were under 18 years of age; * were refused by the patients or his/her familiality; * were suffering from acquired immunodeficiency syndrome,virlhepatitis,autoimmune diseases and hematology; * use medicine which can affect immune system,such as Glucocorticoid and Immunosuppressant * died within 24h after being taken into the ICU, or refused to get involved in the study, or gave up treatment during the period of observation
Countries
China
Outcome results
None listed