Biomarkers in Tumor Samples From Younger Patients With Neuroblastoma

Proposed Studies on the Role of Growth Factor Receptor Trafficking in Neuroblastoma Pathogenesis

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01493830

Enrollment

Registered

2011-12-16

Start date

2011-12-31

Completion date

Unknown

Last updated

2016-07-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Neuroblastoma

Keywords

neuroblastoma

Brief summary

RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This research trial studies biomarkers in tumor samples from younger patients with neuroblastoma.

Detailed description

OBJECTIVES: * To determine the expression of UBE4B, hrs, and members of the ubiquitination protein complex in previously banked primary neuroblastoma tumor samples from the Children's Oncology Group. * To determine the correlation of expression levels and cellular localization of the UBE4B and hrs proteins with growth factor-receptor tumor cell-surface expression. * To determine the 1p36 deletion status by fluorescence in situ hybridization (FISH) analysis and their association with expression levels of UBE4B and hrs in previously banked primary neuroblastoma tumor samples from the Children's Oncology Group. OUTLINE: Banked tumor tissue samples are analyzed for expression of UBE4B, hrs, members of the ubiquitination protein complex, growth factor receptors, and 1p36 deletion status by immunohistochemistry (IHC), fluorescent microscopy, and fluorescence in situ hybridization (FISH).

Interventions

GENETICfluorescence in situ hybridization

GENETICgene expression analysis

GENETICmicroarray analysis

GENETICmutation analysis

GENETICprotein analysis

OTHERimmunohistochemistry staining method

OTHERlaboratory biomarker analysis

OTHERmicroscopy

Study design

Observational model

CASE_ONLY

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

No minimum to 120 Years

Healthy volunteers

Inclusion criteria

DISEASE CHARACTERISTICS: * Tumor tissue microarrays from the Children's Oncology Group neuroblastoma tumor bank PATIENT CHARACTERISTICS: * Not specified PRIOR CONCURRENT THERAPY: * Not specified

Design outcomes

Primary

Measure	Time frame
Expression of UBE4B, hrs, and members of the ubiquitination protein complex	—
Expression levels and cellular localization of the UBE4B, hrs, and growth factor receptors	—
1p36 deletion status and its association with UBE4B	—

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026