Wilms Tumor and Other Childhood Kidney Tumors
Conditions
Brief summary
This research study is studying biomarkers in tissue samples from younger patients with Wilms tumor. Studying samples of tissue from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer. It may also help doctors predict how patients respond to treatment
Detailed description
PRIMARY OBJECTIVES: I. To determine whether recruitment of tumor-associated macrophages is related to clinicopathological factors in Wilms tumor (tumor stage, presence of vascular invasion, tumor progression, and survival). OUTLINE: Paraffin-embedded specimens are analyzed for macrophage markers. Results of each sample are then compared with patient's tumor stage, presence of vascular invasion, tumor progression, and survival.
Interventions
OTHERlaboratory biomarker analysis
Correlative studies
Sponsors
National Cancer Institute (NCI)
Children's Oncology Group
Study design
Observational model
CASE_ONLY
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Wilms tissue microarray samples provided by the Children's Oncology Group
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Relationship of tumor-associated macrophages and prognosis | 1 month | Correlation of each type of macrophage score with tumor staging, presence of vascular invasion, and disease-free survival will be assessed. |
Countries
United States
Outcome results
None listed