Eating Disorders
Conditions
Keywords
Bulimia Nervosa, PET Imaging, Dopamine
Brief summary
This study will use positron emission tomography imaging to investigate the dopamine systems in people with bulimia nervosa.
Interventions
None listed
Sponsors
National Institute of Mental Health (NIMH)
New York State Psychiatric Institute
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
Participants with BN: * Meets DSM-IV criteria for BN * Sufficiently medically and psychiatrically stable to participate in research Health Control Participants: * No current or past psychiatric illness * Between 80% and 120% of ideal body weight
Exclusion criteria
All participants: * Current use of psychotropic medication such as anti psychotics or antidepressants * Pregnant or breastfeeding * history of substance abuse * Significant medical illness * High blood pressure (resting systolic blood pressure greater than 150mmHg and diastolic blood pressure greater that 90 mmHg) * Current or lifetime history of schizophrenia, bipolar disorder, or other psychotic disorder as defined by DSM-IV * Metal implants or paramagnetic objects contained within the body that may interfere with the MRI scan, as determined in consultation with a neuroradiologist and according to specified reference book guidelines * Exposed to radiation in the workplace or has had a nuclear medicine procedure during the 1 year before study entry * Previous adverse reaction to psycho stimulants
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| D2 receptor density | Measured at baseline |
| DA release in the striatum | Measures after Mythlyphenidate challenge |
Countries
United States
Outcome results
None listed